Registered Therapy Dog
Twelve Years, One Month, Twelve Days
|Cadillac Ranch near Amarillo|
|Just outside of Los Vegas|
|I may be a Duchess, but nothing prevents me from a wee nip or two......|
|Trying on her new wheels for the first time|
Canine degenerative myelopathy
- Normal / Normal (N/N, or 'clear'): The dog does not have the mutation and is extremely unlikely to develop degenerative myelopathy. There have been cases in which dogs that tested clear were found to have DM upon necropsy. This information was given to Dr Keller from the OFA. Dr Coates performed necropsy. It is important to note the OFA statement on their website that states "Recent evidence suggest that there are other causes of DM in some breeds".
- Normal / Abnormal (N/A or 'carrier'): The dog has one mutated copy of the gene (is heterozygous) and is a carrier but will not have degenerative myelopathy though there has now been some cases of Carriers developing DM. It will be possible for it to pass the mutation to offspring. A thorough examination of the dog's pedigree and DNA testing should be undertaken prior to breeding a dog with this result.
- Abnormal / Abnormal (A/A or 'At Risk'): The dog has two copies (is homozygous) for the mutation and is at risk for degenerative myelopathy.
- If both parents are clear (N/N) then all of the puppies will be clear
- If one parent is a carrier (N/A) and one is clear (N/N) then roughly 50% of the puppies will be clear and 50% will be carriers
- If both parents are carriers (N/A) then roughly 25% will be clear (N/N), 50% will be carriers (N/A), and 25% will be At risk (A/A)
- If one parent is clear (N/N) and one parent is affected (A/A) then all puppies will be carriers (N/A)
- If one parent is a carrier (N/A) and one is at risk (A/A) then roughly 50% of the puppies will be carriers (N/A) and 50% will be At risk (A/A)
- If both parents are At risk (A/A) then all puppies will be At risk (A/A)